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Nephrol Dial Transplant. 2011 Nov;26(11):3683-8. doi: 10.1093/ndt/gfr098. Epub 2011 Mar 23.

Vitamin D deficiency, self-reported physical activity and health-related quality of life: the Comprehensive Dialysis Study.

Author information

1
Division of Nephrology, Department of Medicine, Stanford University School of Medicine, Palo Alto, CA, USA. sanand2@stanford.edu

Abstract

BACKGROUND:

As research has identified a wide array of biological functions of vitamin D, the consequences of vitamin D deficiency in persons with chronic kidney disease has attracted increased attention. The objective of this study was to determine the extent of 25-hydroxyvitamin D (25-OH vitamin D) deficiency and its associations with self-reported physical activity and health-related quality of life (HRQoL) among participants of the Comprehensive Dialysis Study (CDS).

METHODS:

The nutrition substudy of the CDS enrolled patients new to dialysis from 68 dialysis units throughout the USA. Baseline 25-OH vitamin D concentration was measured using the Direct Enzyme Immunoassay (Immunodiagnostic Systems Inc.). Physical activity was measured with the Human Activity Profile (HAP); the Medical Outcomes Study Short Form-12 (SF-12) was employed to measure HRQoL.

RESULTS:

Mean age of the participants (n = 192) was 62 years. There were 124 participants (65%) with 25-OH vitamin D concentrations < 15 ng/mL, indicating deficiency, and 64 (33%) with 25-OH vitamin D ≥ 15 to <30 ng/mL, indicating insufficiency. After adjusting for age, sex, race/ethnicity, diabetes, season and center, lower 25-OH vitamin D concentrations were independently associated with lower scores on the HAP and on the Mental Component Summary of the SF-12 (P < 0.05 for both), but not with the Physical Component Summary of the SF-12.

CONCLUSION:

In a well-characterized cohort of incident dialysis patients, lower 25-OH vitamin D concentrations were associated with lower self-reported physical activity and poorer self-reported mental health.

PMID:
21430182
PMCID:
PMC3247798
DOI:
10.1093/ndt/gfr098
[Indexed for MEDLINE]
Free PMC Article
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