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J Neurosci. 2011 Mar 23;31(12):4755-64. doi: 10.1523/JNEUROSCI.6594-10.2011.

Erk1/2 inhibit synaptic vesicle exocytosis through L-type calcium channels.

Author information

1
Unit on Behavioral Genetics, Laboratory of Molecular Pathophysiology, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA. subramanianj@mail.nih.gov

Abstract

L-type calcium channels play only a minor role in basal neurotransmitter release in brain neurons but contribute significantly after induction of plasticity. Very little is known about mechanisms that enable L-type calcium channel participation in neurotransmitter release. Here, using mouse primary cortical neurons, we found that inhibition of Erk1/2 (extracellular signal-regulated kinases 1 and 2) enhanced synaptic vesicle exocytosis by increasing calcium influx through L-type calcium channels. Furthermore, inhibition of Erk1/2 increased the surface fraction of these channels. These findings indicate a novel inhibitory effect of Erk1/2 on synaptic transmission through L-type calcium channels.

PMID:
21430174
PMCID:
PMC3065322
DOI:
10.1523/JNEUROSCI.6594-10.2011
[Indexed for MEDLINE]
Free PMC Article

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