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Diabetes Care. 2011 May;34(5):1211-3. doi: 10.2337/dc10-1756. Epub 2011 Mar 23.

Additional autoimmune disease found in 33% of patients at type 1 diabetes onset.

Author information

1
Barbara Davis Center for Childhood Diabetes, Aurora, Colorado, USA. taylor.triolo@ucdenver.edu

Abstract

OBJECTIVE:

We sought to define the prevalence of nonislet, organ-specific autoantibodies at diagnosis of type 1 diabetes and to determine the prevalence of comorbid autoimmune diseases.

RESEARCH DESIGN AND METHODS:

Children (n = 491) diagnosed with type 1 diabetes at the Barbara Davis Center for Childhood Diabetes were screened for autoimmune thyroid disease (thyroid peroxidase autoantibodies [TPOAb]), celiac disease (tissue transglutaminase autoantibodies [TTGAb]), and Addison disease (21-hydroxylase autoantibodies [21OHAb]).

RESULTS:

Of the 491 children, 161 had at least one nonislet autoantibody, and of these, 122 (24.8%) were positive for TPOAb, and 15 of the 122 (12.3%) had autoimmune thyroid disease. There were 57 (11.6%) who were positive for TTGAb, of whom 14 (24.6%) had celiac disease. Five (1.0%) were positive for 21OHAb, of whom one had Addison disease.

CONCLUSIONS:

Many autoantibody-positive subjects present with additional autoimmune disorders. Detection of these autoantibodies at type 1 diabetes onset may prevent complications associated with delayed diagnosis of these disorders.

PMID:
21430083
PMCID:
PMC3114477
DOI:
10.2337/dc10-1756
[Indexed for MEDLINE]
Free PMC Article

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