Format

Send to

Choose Destination
Trends Endocrinol Metab. 2011 May;22(5):179-87. doi: 10.1016/j.tem.2011.02.001. Epub 2011 Mar 21.

Mineralocorticoid receptors in the brain and cardiovascular regulation: minority rule?

Author information

1
Research Service, G.V. (Sonny) Montgomery VA Medical Center and Department of Medicine, Division of Endocrinology, The University of Mississippi Medical Center, Jackson, MO, USA. egomez-sanchez@umc.edu

Abstract

A small proportion of brain mineralocorticoid receptors (MR) mediate control of blood pressure, water and electrolyte balance, sodium appetite, and sympathetic drive to the periphery. Circulating inflammatory cytokines modulate MR-mediated changes in sympathoexcitation. Aldosterone binding to MR in the brain occurs, despite concentrations that are 2-3 orders of magnitude less than those of cortisol and corticosterone, which have similar affinity for the MR. The possible mechanisms for selective MR activation by aldosterone, the cellular mechanisms of MR action and the effects of brain MR on hemodynamic homeostasis are considered in this review. MR antagonists are valuable adjuncts to the treatment of chronic cardiovascular and renal disease; the crucial need to discover targets for development of selective therapy for specific MR functions is also discussed.

PMID:
21429762
PMCID:
PMC3140534
DOI:
10.1016/j.tem.2011.02.001
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center