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Arzneimittelforschung. 2011;61(2):126-31. doi: 10.1055/s-0031-1296178.

Controlled study on thymol + eugenol vaginal douche versus econazole in vaginal candidiasis and metronidazole in bacterial vaginosis.

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1
Azienda Sanitaria n. 3, Corigliano (CS), Italy.

Abstract

PURPOSE OF THE STUDY:

Bacterial vaginosis (BV) and vaginal candidiasis (VC) are usually managed with topical antibiotics. This study compared the efficacy of a thymol + eugenol vaginal douche (SD) (CAS nr. thymol: 89-83-8 and eugenol: 97-53-0), with econazole (CAS 27220-47-9) in VC and metronidazole (CAS 443-48-1) in BV, as suppository reference therapies. Thymol and eugenol are natural antibacterial and antimycotic active ingredients extracted from plants.

METHODS:

A multicentre, parallel group, randomized study was performed, after stratification for diagnosis. Twenty-three Italian gynaecological units enrolled 459 patients (232 BV, 227 VC). The treatments applied were as follows: SD 1 douche/day (Saugella lavanda Attiva) for 1 week, 1 metronidazole vaginal suppository/night for 1 week and 1 econazole vaginal suppository/night for 3 days. Clinical evaluations were performed before and 1 week after treatment.

RESULTS:

A similar significant symptom reduction was observed with metronidazole and SD in BV and with econazole and SD in VC.

CONCLUSION:

SD was found to be an effective prescription drug in minor recurrent vaginal infectious episodes and its use can reduce the repeated exposure to antibiotics.

PMID:
21428248
DOI:
10.1055/s-0031-1296178
[Indexed for MEDLINE]

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