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Retina. 2011 Jun;31(6):1083-8. doi: 10.1097/IAE.0b013e318207d1a3.

Ranibizumab for the treatment of exudative age-related macular degeneration associated with retinal pigment epithelial tear.

Author information

1
Second Department of Ophthalmology, Medical School of Athens University, Athens, Greece. rallex@hol.gr

Abstract

PURPOSE:

To evaluate the efficacy of intravitreal ranibizumab in eyes with exudative age-related macular degeneration associated with retinal pigment epithelial tear.

METHODS:

In this retrospective case series, patients with active exudative age-related macular degeneration associated with retinal pigment epithelial tear were treated by repeated injections of intravitreal ranibizumab. The outcome measures were best-corrected visual acuity and the signs of lesion activity, as evaluated by optical coherence tomography, fluorescein angiography, and indocyanine green angiography.

RESULTS:

Twenty-one eyes of 20 patients were followed-up for a median of 12 months (range, 6-28 months). The median number of injections was 7 (range, 3-15). The best-corrected visual acuity improved in 6 eyes (28.57%), remained stable in 12 (57.14%), and decreased in 3 (14.28%). At the end of the follow-up time, 19 eyes (90.47%) had an inactive neovascular lesion in angiography, while 18 eyes (85.71%) had no signs of intraretinal or subretinal fluid.

CONCLUSION:

Intravitreal ranibizumab was effective in improving or stabilizing vision and resulting in a quiescent lesion in the majority of patients with exudative age-related macular degeneration associated with retinal pigment epithelial tear. The functional results were apparently better in eyes without foveal involvement by the retinal pigment epithelial tear.

PMID:
21427630
DOI:
10.1097/IAE.0b013e318207d1a3
[Indexed for MEDLINE]

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