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Nano Lett. 2011 Apr 13;11(4):1469-76. doi: 10.1021/nl104079r. Epub 2011 Mar 22.

Impact of local versus global ligand density on cellular adhesion.

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1
Department of New Materials and Biosystems, Max Planck Institute for Intelligent Systems, Heisenbergstrasse 3, 70569 Stuttgart, Germany.

Abstract

α(v)β(3) integrin-mediated cell adhesion is crucially influenced by how far ligands are spaced apart. To evaluate the impact of local ligand density versus global ligand density of a given surface, we used synthetic micronanostructured cell environments with user-defined ligand spacing and patterns to investigate cellular adhesion. The development of stable focal adhesions, their number, and size as well as the cellular adhesion strength proved to be influenced by local more than global ligand density.

PMID:
21425841
PMCID:
PMC3806292
DOI:
10.1021/nl104079r
[Indexed for MEDLINE]
Free PMC Article
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