Format

Send to

Choose Destination
See comment in PubMed Commons below
Birth Defects Res A Clin Mol Teratol. 2011 Aug;91(8):652-65. doi: 10.1002/bdra.20781. Epub 2011 Mar 21.

Epigenetic programming: from gametes to blastocyst.

Author information

1
Department of Pharmacology and Therapeutics, McGill University, Montréal, Québec, Canada. Barbara.hales@mcgill.ca

Abstract

Embryo development requires a series of cell fate decisions; cell lineages are established early during development and must be "remembered" through multiple cell divisions. It is increasingly evident that epigenetic marks, DNA methylation, histone modifications, and noncoding RNAs, have a critical role in this cell memory during development. During gametogenesis, epigenetic programming results in the production of spermatozoa and oocytes with distinctive chromatin. The goal of this article is to review what is known about the epigenetic marks in mature gametes and how these marks change during early embryo development. An understanding of the role of epigenetic programming during normal development will lay the basis for the elucidation of its role when development goes awry and the consequence is a birth defect.

PMID:
21425433
DOI:
10.1002/bdra.20781
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Support Center