Co/Mn-mediated oxidative cross-coupling of indoles with β-keto esters via dioxygen activation: an efficient access to ketonization-olefination of indoles

Chem Commun (Camb). 2011 Sep 14;47(34):9660-2. doi: 10.1039/c1cc10545k. Epub 2011 Mar 18.

Abstract

The Co/Mn-mediated oxidative cross-coupling of indoles with β-keto esters via dioxygen activation under mild conditions leads to ketonization-olefination of indoles. This reaction furnishes the highly functionalized products with excellent selectivity in good yields.

MeSH terms

  • Alkenes / chemistry*
  • Cobalt / chemistry*
  • Esters
  • Indoles / chemistry*
  • Ketones / chemistry*
  • Manganese / chemistry*
  • Oxidative Coupling*
  • Oxygen / chemistry*

Substances

  • Alkenes
  • Esters
  • Indoles
  • Ketones
  • Cobalt
  • Manganese
  • Oxygen