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Org Biomol Chem. 2011 May 7;9(9):3130-2. doi: 10.1039/c1ob05097d. Epub 2011 Mar 21.

Structure elucidation and biosynthesis of lysine-rich cyclic peptides in Xenorhabdus nematophila.

Author information

1
Molekulare Biotechnologie, Institut für Molekulare Biowissenschaften, Goethe Universität Frankfurt, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany.

Abstract

Thirteen novel PAX (peptide-antimicrobial-Xenorhabdus) peptides were identified in Xenorhabdus nematophila HGB081. Their structures including the absolute configuration were elucidated using a combination of labeling experiments, detailed MS/MS experiments, the advanced Marfey's method, and a detailed analysis of the biosynthesis gene cluster, which was identified as well.

PMID:
21423922
DOI:
10.1039/c1ob05097d
[Indexed for MEDLINE]

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