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Front Synaptic Neurosci. 2010 Sep 16;2:144. doi: 10.3389/fnsyn.2010.00144. eCollection 2010.

What is Rate-Limiting during Sustained Synaptic Activity: Vesicle Supply or the Availability of Release Sites.

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Department of Membrane Biophysics, Max Planck Institute for Biophysical Chemistry Goettingen, Germany.


For some types of synapses the availability of release-ready vesicles is a limiting factor during ongoing activity. Synaptic strength in this case is determined both by the recruitment of such vesicles and the probability of their release during an action potential. Here it is argued that not the availability of vesicles is the limiting factor for recruitment, but rather the availability of specific sites to which vesicles can dock.


calyx of Held; endocytosis; exocytosis; neurotransmitter release; synapse

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