Format

Send to

Choose Destination
See comment in PubMed Commons below
Front Synaptic Neurosci. 2010 Jun 9;2:9. doi: 10.3389/fnsyn.2010.00009. eCollection 2010.

STDP in the Developing Sensory Neocortex.

Author information

1
Department of Cell and Molecular Physiology, The University of North Carolina at Chapel Hill Chapel Hill, NC, USA.

Abstract

Spike timing-dependent plasticity (STDP) has been proposed as a mechanism for optimizing the tuning of neurons to sensory inputs, a process that underlies the formation of receptive field properties and associative memories. The properties of STDP must adjust during development to enable neurons to optimally tune their selectivity for environmental stimuli, but these changes are poorly understood. Here we review the properties of STDP and how these may change during development in primary sensory cortical layers 2/3 and 4, initial sites for intracortical processing. We provide a primer discussing postnatal developmental changes in synaptic proteins and neuromodulators that are thought to influence STDP induction and expression. We propose that STDP is shaped by, but also modifies, synapses to produce refinements in neuronal responses to sensory inputs.

KEYWORDS:

auditory cortex; endocannabinoid; neuromodulation; presynaptic NMDA receptor; somatosensory cortex; spike timing-dependent plasticity; visual cortex

PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Frontiers Media SA Icon for PubMed Central
    Loading ...
    Support Center