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Cell Res. 2011 Apr;21(4):564-78. doi: 10.1038/cr.2011.42. Epub 2011 Mar 22.

Readers of histone modifications.

Author information

1
Department of Molecular Biology, UT Southwestern Medical Center, Dallas, TX 75390-9148, USA.

Abstract

Histone modifications not only play important roles in regulating chromatin structure and nuclear processes but also can be passed to daughter cells as epigenetic marks. Accumulating evidence suggests that the key function of histone modifications is to signal for recruitment or activity of downstream effectors. Here, we discuss the latest discovery of histone-modification readers and how the modification language is interpreted.

PMID:
21423274
PMCID:
PMC3131977
DOI:
10.1038/cr.2011.42
[Indexed for MEDLINE]
Free PMC Article

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