Format

Send to

Choose Destination
Cerebrovasc Dis. 2011;31(5):511-7. doi: 10.1159/000324391. Epub 2011 Mar 21.

Comparison of 7.0-T T₂*-magnetic resonance imaging of cerebral bleeds in post-mortem brain sections of Alzheimer patients with their neuropathological correlates.

Author information

1
Université Lille Nord de France, UDSL, EA 1056, Lille, France. dereuck.j@gmail.com

Abstract

BACKGROUND:

In view of the increasing recognition of cerebral microbleeds (MCBs) with MRI, there is a need to validate their detection in post-mortem brains in patients with cerebrovascular diseases and dementia.

MATERIALS AND METHODS:

Out of 20 post-mortem brains of patients with Alzheimer dementia and with different cerebrovascular lesions, 45 large sections of the cerebral hemispheres, brainstem and cerebellum were submitted to a 7.0-T T₂*-weighted MRI, and afterwards compared to the histological detection of haematomas, MCBs and mini-bleeds (MNBs).

RESULTS:

The sensitivity, specificity, predictive positive value and predictive negative value of the T₂* imaging to detect MCBs and MNBs were excellent for those in the cortico-subcortical regions. There was a significant overestimation of MNBs in the striatum due to iron deposits unrelated to old haemorrhages. Also in the deep white matter, 42% of MNBs were not detected, while 31% of T₂* hyposignals were not due to MNBs but to vessels filled with post-mortem thrombi.

CONCLUSIONS:

When evaluating the 'bleeding load' with 7.0-T T₂*-weighted MRI in post-mortem brain sections of patients with dementia and vascular risk factors, only quantification of small cerebral bleeds in the cortico-subcortical regions is reliable.

PMID:
21422755
DOI:
10.1159/000324391
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for S. Karger AG, Basel, Switzerland
Loading ...
Support Center