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Antimicrob Agents Chemother. 2011 Jun;55(6):3015-7. doi: 10.1128/AAC.00575-10. Epub 2011 Mar 21.

Synergistic effect of 14-alpha-lipoyl andrographolide and various antibiotics on the formation of biofilms and production of exopolysaccharide and pyocyanin by Pseudomonas aeruginosa.

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1
Institute of New Drug Research, Jinan University College of Pharmacy, Guangzhou 510632, China.

Abstract

Pseudomonas aeruginosa produces a biofilm that provides the bacteria with an effective barrier against antibiotics. Here, we investigated the synergy of various antibiotics with 14-alpha-lipoyl andrographolide (AL-1), focusing upon synthesis of the biofilm. AL-1 also inhibited the production of the exopolysaccharide and pyocyanin components. We propose that AL-1 may potentially serve as a cotherapy to combat P. aeruginosa.

PMID:
21422201
PMCID:
PMC3101388
DOI:
10.1128/AAC.00575-10
[Indexed for MEDLINE]
Free PMC Article
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