Format

Send to

Choose Destination
Cold Spring Harb Perspect Biol. 2011 Feb 1;3(2). pii: a004911. doi: 10.1101/cshperspect.a004911.

Basement membranes: cell scaffoldings and signaling platforms.

Author information

1
Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA. yurchenc@umdnj.edu

Abstract

Basement membranes are widely distributed extracellular matrices that coat the basal aspect of epithelial and endothelial cells and surround muscle, fat, and Schwann cells. These extracellular matrices, first expressed in early embryogenesis, are self-assembled on competent cell surfaces through binding interactions among laminins, type IV collagens, nidogens, and proteoglycans. They form stabilizing extensions of the plasma membrane that provide cell adhesion and that act as solid-phase agonists. Basement membranes play a role in tissue and organ morphogenesis and help maintain function in the adult. Mutations adversely affecting expression of the different structural components are associated with developmental arrest at different stages as well as postnatal diseases of muscle, nerve, brain, eye, skin, vasculature, and kidney.

PMID:
21421915
PMCID:
PMC3039528
DOI:
10.1101/cshperspect.a004911
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center