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J Antimicrob Chemother. 2011 Jun;66(6):1298-300. doi: 10.1093/jac/dkr108. Epub 2011 Mar 18.

In vitro synergistic effects of baicalin with oxytetracycline and tetracycline against Staphylococcus aureus.

Author information

1
Department of Crop Sciences and Agroforestry, Institute of Tropics and Subtropics, Czech University of Life Sciences Prague, Kamycka 129, 16521 Prague 6-Suchdol, Czech Republic.

Abstract

OBJECTIVES:

In this study we examined the in vitro synergistic effect of baicalin, the flavone constituent of Scutellaria spp., in combinations with oxytetracycline and tetracycline on the growth of Staphylococcus aureus.

METHODS:

The MICs were determined by the broth microdilution method and the effect of combinations was evaluated according to the sum of fractional inhibitory concentration indices (FICIs).

RESULTS:

Synergistic activity (FICI  ≤  0.5) was observed for combinations of baicalin with oxytetracycline or tetracycline against 4 of 10 strains tested, whereas the baicalin/oxytetracycline combination possessed the strongest synergistic effect (FICI = 0.418).

CONCLUSIONS:

Baicalin acts synergistically with oxytetracycline and tetracycline, enhancing its antimicrobial activity against S. aureus, including methicillin- and tetracycline-resistant strains.

PMID:
21421582
DOI:
10.1093/jac/dkr108
[Indexed for MEDLINE]

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