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Cell. 1990 Jun 29;61(7):1217-24.

A specific member of the ATF transcription factor family can mediate transcription activation by the adenovirus E1a protein.

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Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, Massachusetts 02138.


The adenovirus E1a protein stimulates transcription of viral early genes. Recent experiments indicate that E1a contains a transcriptional activating region, which functions when directed to a promoter. Because E1a is not a sequence-specific DNA binding protein, how it targets to viral promoters has been a question. Several of the viral early promoters contain one or more binding sites for ATFs, a family of cellular transcription factors. Here we show that E1a can function through a specific ATF protein, designated ATF-2. We provide evidence that E1a interacts with a discrete region of promoter-bound ATF-2, thereby positioning the E1a activating region at a viral promoter.

[Indexed for MEDLINE]

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