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Mol Cell. 2011 Mar 18;41(6):621-3. doi: 10.1016/j.molcel.2011.03.001.

UPF1 learns to relax and unwind.

Author information

1
Department of Biochemistry and Biophysics, School of Medicine and Dentistry, University of Rochester, Rochester, NY 14642, USA. michael_gleghorn@urmc.rochester.edu

Abstract

In this issue of Molecular Cell, Chakrabarti et al. (2011) structurally reveal how UPF1, an RNA helicase that plays a central role in nonsense-mediated mRNA decay, is conformationally converted from a largely inactive state to an active state upon UPF2 binding.

PMID:
21419337
DOI:
10.1016/j.molcel.2011.03.001
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