Format

Send to

Choose Destination
See comment in PubMed Commons below
J Hematol Oncol. 2011 Mar 22;4:10. doi: 10.1186/1756-8722-4-10.

Mast cell activation disease: a concise practical guide for diagnostic workup and therapeutic options.

Author information

1
Institute of Human Genetics, University Hospital of Bonn, Germany. molderings@uni-bonn.de

Abstract

Mast cell activation disease comprises disorders characterized by accumulation of genetically altered mast cells and/or abnormal release of these cells' mediators, affecting functions in potentially every organ system, often without causing abnormalities in routine laboratory or radiologic testing. In most cases of mast cell activation disease, diagnosis is possible by relatively non-invasive investigation. Effective therapy often consists simply of antihistamines and mast cell membrane-stabilising compounds supplemented with medications targeted at specific symptoms and complications. Mast cell activation disease is now appreciated to likely be considerably prevalent and thus should be considered routinely in the differential diagnosis of patients with chronic multisystem polymorbidity or patients in whom a definitively diagnosed major illness does not well account for the entirety of the patient's presentation.

PMID:
21418662
PMCID:
PMC3069946
DOI:
10.1186/1756-8722-4-10
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for BioMed Central Icon for PubMed Central
    Loading ...
    Support Center