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J Biomed Sci. 2011 Mar 22;18:23. doi: 10.1186/1423-0127-18-23.

Composition and conservation of the mRNA-degrading machinery in bacteria.

Author information

1
Institute of Molecular Biology, Academia Sinica, Taipei 11529, Taiwan. vladimir_kaberdin@ehu.es

Abstract

RNA synthesis and decay counteract each other and therefore inversely regulate gene expression in pro- and eukaryotic cells by controlling the steady-state level of individual transcripts. Genetic and biochemical data together with recent in depth annotation of bacterial genomes indicate that many components of the bacterial RNA decay machinery are evolutionarily conserved and that their functional analogues exist in organisms belonging to all kingdoms of life. Here we briefly review biological functions of essential enzymes, their evolutionary conservation and multienzyme complexes that are involved in mRNA decay in Escherichia coli and discuss their conservation in evolutionarily distant bacteria.

PMID:
21418661
PMCID:
PMC3071783
DOI:
10.1186/1423-0127-18-23
[Indexed for MEDLINE]
Free PMC Article
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