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HPB (Oxford). 2011 Apr;13(4):240-5. doi: 10.1111/j.1477-2574.2010.00277.x. Epub 2011 Jan 28.

Prognostic significance of lymph node ratio after resection of peri-hilar cholangiocarcinoma.

Author information

1
Department of Surgery, Division of General Surgery A, GB Rossi Hospital, University of Verona, Verona, Italy. alfredo.guglielmi@univr.it

Abstract

BACKGROUND:

Lymph node (LN) metastases are a major negative prognostic factor for peri-hilar cholangiocarcinoma (PCC). Prognostic significance of the extent of LN dissection, number of metastatic LN and the lymph node ratio (LNR) are still under debate.

AIMS:

The aims of the present study were to evaluate the prognostic value of the LN status, the total number of LNs evaluated and LNR in PCC.

METHODS:

Between 1990 and 2008, 62 patients with PCC submitted to surgical resection with curative intent were retrospectively evaluated. Number and status of harvested LN were recorded.

RESULTS:

In 53 patients (85.4%) regional lymphadenectomy was performed. Median number of LNs examined was 7 (range 1-25). Median survival was 41.9 months in patients with N0 compared with 22.7 months in 21 patients (39.6%) with N+ (P= 0.03). Median survival was 3, 18.5 and 29 months for patients with 0, 1-3 and >3 LN retrieved, respectively (P < 0.01). Five-year survival for patients above and below the LNR cut-off value of 0.25 was 0% and 22.5%, respectively (P= 0.03).

CONCLUSIONS:

LN metastases are a major prognostic factor for survival after surgical resection of PCC. The number of LN harvested and LNR showed high prognostic value.

PMID:
21418129
PMCID:
PMC3081624
DOI:
10.1111/j.1477-2574.2010.00277.x
[Indexed for MEDLINE]
Free PMC Article

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