Abstract
Two types of nonwoven fabric, consisting of siloxane-doped vaterite (SiV) and poly(lactic acid) (PLA), for guided bone regeneration (GBR) were prepared by an electrospinning. One of the fabrics, SiV-PLA(M), was derived from PLA mixed with the solution of SiV dispersed in chloroform. Another one, SiV-PLA(K), was derived from a composite prepared by kneading SiV and PLA while heating at 200°C. The SiV-PLA(K) fabric shows higher degradability in dilute NaOH aq. than the SiV-PLA(M) fabric. To improve the cellular compatibility of the fabric, the fibers were coated with hydroxyapatite (HA) by soaking in simulated body fluid. The HA-coated SiV-PLA(K) fabric showed the release of silicate ions; the amount was reduced by 1/5 to 1/8 compared with that of the HA-coated SiV-PLA(M) fabric, and the excessive release was controlled. The preparation route of kneading at 200°C led to formation of a fabric with degradation behavior and ion releasability effective for bone regeneration.
Publication types
-
Comparative Study
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Biocompatible Materials / chemistry*
-
Body Fluids / chemistry
-
Calcium / chemistry
-
Calcium Carbonate / chemistry*
-
Calorimetry, Differential Scanning
-
Chemical Phenomena
-
Chloroform / chemistry
-
Coated Materials, Biocompatible / chemistry
-
Crystallography
-
Diffusion
-
Durapatite / chemistry
-
Electrochemical Techniques
-
Fixatives / chemistry
-
Guided Tissue Regeneration / instrumentation*
-
Hot Temperature
-
Humans
-
Hydrolysis
-
Lactic Acid / chemistry*
-
Materials Testing
-
Membranes, Artificial*
-
Microscopy, Electron, Scanning
-
Molecular Weight
-
Polyesters
-
Polymers / chemistry*
-
Silicates / chemistry
-
Siloxanes / chemistry*
-
Sodium Hydroxide / chemistry
-
Spectroscopy, Fourier Transform Infrared
-
Surface Properties
-
Time Factors
Substances
-
Biocompatible Materials
-
Coated Materials, Biocompatible
-
Fixatives
-
Membranes, Artificial
-
Polyesters
-
Polymers
-
Silicates
-
Siloxanes
-
Lactic Acid
-
poly(lactide)
-
Sodium Hydroxide
-
Chloroform
-
Durapatite
-
Calcium Carbonate
-
Calcium