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Indian J Med Res. 2011 Feb;133:195-200.

Molecular mechanism of acquisition of the cholera toxin genes.

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1
CNRS, Centre de Génétique Moléculaire, Gif-sur-Yvette & Université Paris-Sud, Orsay, France.

Abstract

One of the major pathogenic determinants of Vibrio cholerae, the cholera toxin, is encoded in the genome of a filamentous phage, CTXφ. CTXφ makes use of the chromosome dimer resolution system of V. cholerae to integrate its single stranded genome into one, the other, or both V. cholerae chromosomes. Here, we review current knowledge about this smart integration process.

PMID:
21415494
PMCID:
PMC3089051
[Indexed for MEDLINE]
Free PMC Article
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