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Br J Psychiatry. 2011 May;198(5):404-5. doi: 10.1192/bjp.bp.110.085944. Epub 2011 Mar 17.

Season of birth and anorexia nervosa.

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1
Wellcome Trust Centre for Human Genetics, University of Oxford and Department of Clinical Neurology, University of Oxford, John Radcliffe Hospital, Oxford, UK.

Abstract

Our aim was to investigate whether there is a season-of-birth effect in anorexia nervosa. In a meta-analysis, we compared the distribution of anorexia births (n = 1293) from four independent UK cohorts to that of the general UK population (n = 21 914 037), using both the Walter & Elwood seasonality and chi-squared tests. We found an excess of anorexia births from March to June (odds ratio (OR) = 1.15, 95% CI 1.03-1.29, P = 0.012) and a deficit from September to October (OR = 0.8, 95% CI 0.68-0.94, P = 0.007). These results indicate that environmental risk factor(s) are operative during gestation or immediately after birth and their identification will be important for disease prevention strategies.

PMID:
21415047
PMCID:
PMC3093677
DOI:
10.1192/bjp.bp.110.085944
[Indexed for MEDLINE]
Free PMC Article
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