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Cell. 2011 Mar 18;144(6):844-9. doi: 10.1016/j.cell.2011.03.008.

Network news: innovations in 21st century systems biology.

Author information

1
Department of Bioengineering, University of California, Berkeley, Berkeley, CA 94720, USA. aparkin@lbl.gov

Abstract

A decade ago, seminal perspectives and papers set a strong vision for the field of systems biology, and a number of these themes have flourished. Here, we describe key technologies and insights that have elucidated the evolution, architecture, and function of cellular networks, ultimately leading to the first predictive genome-scale regulatory and metabolic models of organisms. Can systems approaches bridge the gap between correlative analysis and mechanistic insights?

PMID:
21414475
DOI:
10.1016/j.cell.2011.03.008
[Indexed for MEDLINE]
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