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J Med Chem. 2011 Apr 14;54(7):2492-503. doi: 10.1021/jm200039m. Epub 2011 Mar 17.

A one-pot synthesis and biological activity of ageladine A and analogues.

Author information

1
Department of Chemistry & Biomolecular Sciences, Macquarie University, Sydney NSW-2109, Australia.

Abstract

A one-pot synthesis of ageladine A and analogues is reported. The key Pictet-Spengler reaction between 2-aminohistamine and aryl aldehydes has been successfully utilized for the synthesis of the natural product and 14 analogues. These compounds were screened for their matrix metalloprotease (MMP) and kinase inhibition to develop the first structure-activity relationship of ageladine A analogues. One compound, which showed significant kinase activity but little MMP inhibitory activity, was found to be highly active in an antiangiogenic screen, suggesting that the angiogenic activity of ageladine A is not associated with MMP inhibition but rather kinase inhibitory activity. Cytotoxicity was excluded as a mode of action by the assay of ageladine A and an analogue against 60 human cell lines.

PMID:
21413800
DOI:
10.1021/jm200039m
[Indexed for MEDLINE]

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