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Phytother Res. 2011 Nov;25(11):1612-7. doi: 10.1002/ptr.3465. Epub 2011 Mar 16.

Protective effect of components isolated from Lindera erythrocarpa against oxidative stress-induced apoptosis of H9c2 cardiomyocytes.

Author information

1
College of Pharmacy, Chungnam National University, Daejeon 305-764, Korea.

Abstract

Eight compounds were isolated from the methanol fraction of Lindera erythrocarpa and assessed for their ability to protect H9c2 cardiomyocytes against oxidative stress-induced cell death. Three of the compounds significantly reduced the release of lactate dehydrogenase from H9c2 cardiomyocytes treated with buthionine-[S,R]-sulfoximine and reduced the uptake of propidium iodide by these cells. These effects were concentration-dependent. The three inhibitory compounds were identified as (-)-epicatechin, avicularin and quercitrin by spectroscopic techniques including one- and two-dimensional NMR and mass spectroscopy.

PMID:
21412863
DOI:
10.1002/ptr.3465
[Indexed for MEDLINE]

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