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Arch Ital Biol. 2011 Mar;149(1):65-82. doi: 10.4449/aib.v149i1.1262.

Genetics of familial Amyotrophic lateral sclerosis.

Author information

1
Department of Neurology and Laboratory of Neuroscience IRCCS Istituto Auxologico Italiano, 20149 Milan, Italy. n.ticozzi@fastwebnet.it

Abstract

Amyotrophic lateral sclerosis (ALS) is a late onset, rapidly progressive and ultimately fatal neurodegenerative disease, caused by the loss of motor neurons in the brain and spinal cord. About 10% of all ALS cases are familial (FALS), and constitute a clinically and genetically heterogeneous entity. To date, FALS has been linked to mutations in 10 different genes and to four additional chromosomal loci. Research on FALS genetics, and in particular the discoveries of mutations in the SOD1, TARDBP, and FUS genes, has provided essential information toward the understanding of the pathogenesis of ALS in general. This review presents a tentative classification of all FALS-associated genes identified so far.

PMID:
21412717
DOI:
10.4449/aib.v149i1.1262
[Indexed for MEDLINE]

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