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Autophagy. 2011 May;7(5):541-3. Epub 2011 May 1.

Oxidized LDLs trigger endoplasmic reticulum stress and autophagy: prevention by HDLs.

Author information

1
INSERM U-1048/I2MC, University Paul Sabatier, Toulouse, France.

Abstract

Oxidized LDLs (oxLDLs) induce various cellular dysfunctions potentially implicated in the pathogenesis of atherosclerosis. For instance, toxic concentrations of oxLDLs trigger ER stress, autophagy and apoptosis. High-density lipoproteins (HDLs) counteract several adverse biological effects triggered by oxLDLs. Our recent study reveals that HDLs inhibit the activation of ER stress and of autophagy induced by oxLDLs.

PMID:
21412049
DOI:
10.4161/auto.7.5.15003
[Indexed for MEDLINE]

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