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RETRACTED ARTICLE

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Cell. 1990 Jun 15;61(6):1013-20.

Renaturation of denatured lambda repressor requires heat shock proteins.

Author information

1
Institute of Cancer Research, College of Physicians & Surgeons, Columbia University, New York, New York 10032.

Abstract

The temperature-sensitive bacteriophage lambda cI857 repressor protein rapidly renatures after thermal inactivation. E. coli mutants in the heat shock protein genes dnaK, dnaJ, and grpE do not efficiently reactivate heat-denatured repressor. Our results suggest that protein refolding is promoted by heat shock proteins and that such a process is the basis of the homeostatic role played by these proteins in the heat shock response.

PMID:
2140957
DOI:
10.1016/0092-8674(90)90066-n
[Indexed for MEDLINE]

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