"Inosaminoacids": novel inositol-amino acid hybrid structures accessed by microbial arene oxidation

Chem Commun (Camb). 2011 Apr 28;47(16):4799-801. doi: 10.1039/c1cc10643k. Epub 2011 Mar 15.

Abstract

Microbial 1,2-dihydroxylation of sodium benzoate permits the rapid construction of novel inositol-amino acid hybrid structures. Both β- and γ-amino acids are accessible by means of an acylnitroso Diels-Alder cycloaddition.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acids / chemistry*
  • Crystallography, X-Ray
  • Cyclization
  • Inositol / chemistry*
  • Models, Molecular
  • Molecular Structure
  • Oxidation-Reduction
  • Sodium Benzoate / chemistry*
  • Stereoisomerism

Substances

  • Amino Acids
  • Inositol
  • Sodium Benzoate