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PLoS One. 2011 Mar 2;6(3):e17637. doi: 10.1371/journal.pone.0017637.

Rapid cellular turnover in adipose tissue.

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1
Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University, Boston, Massachusetts, United States of America.

Abstract

It was recently shown that cellular turnover occurs within the human adipocyte population. Through three independent experimental approaches--dilution of an inducible histone 2B-green fluorescent protein (H2BGFP), labeling with the cell cycle marker Ki67 and incorporation of BrdU--we characterized the degree of cellular turnover in murine adipose tissue. We observed rapid turnover of the adipocyte population, finding that 4.8% of preadipocytes are replicating at any time and that between 1-5% of adipocytes are replaced each day. In light of these findings, we suggest that adipose tissue turnover represents a possible new avenue of therapeutic intervention against obesity.

PMID:
21407813
PMCID:
PMC3047582
DOI:
10.1371/journal.pone.0017637
[Indexed for MEDLINE]
Free PMC Article
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