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Eur J Hum Genet. 2011 Aug;19(8):833-6. doi: 10.1038/ejhg.2011.25. Epub 2011 Mar 16.

Strengthening the reporting of genetic risk prediction studies: the GRIPS statement.

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Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.


The rapid and continuing progress in gene discovery for complex diseases is fueling interest in the potential application of genetic risk models for clinical and public health practice. The number of studies assessing the predictive ability is steadily increasing, but the quality and completeness of reporting varies. A multidisciplinary workshop sponsored by the Human Genome Epidemiology Network developed a checklist of 25 items recommended for strengthening the reporting of Genetic RIsk Prediction Studies, building on the principles established by previous reporting guidelines. These recommendations aim to enhance the transparency of study reporting, and thereby to improve the synthesis and application of information from multiple studies that might differ in design, conduct, or analysis. A detailed Explanation and Elaboration document is published on the EJHG website.

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