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Apoptosis. 2011 Apr;16(4):321-33. doi: 10.1007/s10495-011-0589-x.

Conversation between apoptosis and autophagy: "Is it your turn or mine?".

Author information

1
IGM-Consiglio Nazionale delle Ricerche, Via Abbiategrasso 207, Pavia, Italy.

Abstract

Drug resistance of cancer cells is often correlated with apoptosis evasion; however, an active involvement of autophagy in this scenario has been recently proposed, based on the evidence that autophagy could exert a protective role toward the activation of apoptosis in cancer cells. In this review, we briefly review the basic features of apoptosis, and we describe in details the molecular patterns of autophagy, with a special emphasis on its still controversial physiological function(s). The crucial factors governing the cross talk between autophagy and apoptosis will be illustrated.

PMID:
21404107
DOI:
10.1007/s10495-011-0589-x
[Indexed for MEDLINE]

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