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Infect Immun. 2011 May;79(5):1927-35. doi: 10.1128/IAI.00046-11. Epub 2011 Mar 14.

Role of the accessory gene regulator agr in community-associated methicillin-resistant Staphylococcus aureus pathogenesis.

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1
Laboratory of Human Bacterial Pathogenesis, NIAID, NIH, Bldg. 33, 1W10, 9000 Rockville Pike, Bethesda, MD 20892, USA.

Abstract

The molecular basis underlying the pathogenic success of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) is not completely understood, but differential gene expression has been suggested to account at least in part for the high virulence of CA-MRSA strains. Here, we show that the agr gene regulatory system has a crucial role in the development of skin infections in the most prevalent CA-MRSA strain USA300. Importantly, our data indicate that this is due to discrepancies between the agr regulon of CA-MRSA and those of hospital-associated MRSA and laboratory strains. In particular, agr regulation in strain USA300 led to exceptionally strong expression of toxins and exoenzymes, upregulation of fibrinogen-binding proteins, increased capacity to bind fibrinogen, and increased expression of methicillin resistance genes. Our findings demonstrate that agr functionality is critical for CA-MRSA disease and indicate that an adaptation of the agr regulon contributed to the evolution of highly pathogenic CA-MRSA.

PMID:
21402769
PMCID:
PMC3088142
DOI:
10.1128/IAI.00046-11
[Indexed for MEDLINE]
Free PMC Article
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