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J Infect Dis. 2011 Apr 1;203(7):976-83. doi: 10.1093/infdis/jiq143.

Factors associated with viral rebound in HIV-1-infected individuals enrolled in a therapeutic HIV-1 gag vaccine trial.

Author information

1
Section of Retroviral Therapeutics, Brigham and Women's Hospital, Boston, Massachusetts 02139, USA.

Erratum in

  • J Infect Dis. 2011 Aug;204(4):664.

Abstract

BACKGROUND:

Human immunodeficiency virus type 1 (HIV-1) vaccines directed to the cell-mediated immune system could have a role in lowering the plasma HIV-1 RNA set point, which may reduce infectivity and delay disease progression.

METHODS:

Randomized, placebo-controlled trial involving HIV-1-infected participants who received a recombinant adenovirus serotype 5 (rAd5) HIV-1 gag vaccine or placebo. Sequence-based HLA typing was performed for all 110 participants who initiated analytic treatment interruption (ATI) to assess the role of HLA types previously associated with HIV prognosis. Plasma HIV-1 gag and pol RNA sequences were obtained during the ATI. Virologic endpoints and HLA groups were compared between treatment arms using the 2-sample rank sum test. A linear regression model was fitted to derive independent correlates of ATI week 16 plasma viral load (w16 PVL).

RESULTS:

Vaccinated participants with neutral HLA alleles had lower median w16 PVLs than did vaccinated participants with protective HLA alleles (P = .01) or placebo participants with neutral HLA alleles (P = .02). Factors independently associated with lower w16 PVL included lower pre-antiretroviral therapy PVL, greater Gag sequence divergence from the vaccine sequence, decreased proportion of HLA-associated polymorphisms in Gag, and randomization to the vaccine arm.

CONCLUSIONS:

Therapeutic vaccination with a rAd5-HIV gag vaccine was associated with lower ATI week 16 PVL even after controlling for viral and host genetic factors.

CLINICAL TRIALS REGISTRATION:

NCT00080106.

PMID:
21402549
PMCID:
PMC3068025
DOI:
10.1093/infdis/jiq143
[Indexed for MEDLINE]
Free PMC Article

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