Format

Send to

Choose Destination
J Infect Dis. 2011 Apr 1;203(7):943-7. doi: 10.1093/infdis/jiq154.

A common HLA-DPA1 variant is a major determinant of hepatitis B virus clearance in Han Chinese.

Author information

1
Basic Research Laboratory, SAIC-Frederick, Maryland, USA. Ping.An@nih.gov

Abstract

A recent genome-wide study showed that the single nucleotide polymorphisms (SNPs) in the HLA-DP region were associated with chronic hepatitis B virus (HBV) infection in Japanese and Thai persons. We tested the effects of HLA-DP SNPs for all major HBV outcomes in Han Chinese (n = 1742): HBV resistance, clearance, chronic infection, cirrhosis, and hepatocellular carcinoma. HLA - DPA1 rs3077 T was strongly associated with decreased risk of chronic HBV infection (odds ratio, .62; P = .001), consistent with the previous report. We showed for the first time to our knowledge that it is a predictor for HBV clearance (odds ratio, 2.41; P < .001). However, rs3077 was not associated with the development of cirrhosis or hepatocellular carcinoma.

PMID:
21402545
PMCID:
PMC3068033
DOI:
10.1093/infdis/jiq154
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Silverchair Information Systems Icon for PubMed Central
Loading ...
Support Center