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FEBS Lett. 2011 Jun 6;585(11):1537-42. doi: 10.1016/j.febslet.2011.03.015. Epub 2011 Mar 12.

Calorie restriction and prevention of age-associated chronic disease.

Author information

1
Division of Geriatrics and Nutritional Science, Washington University School of Medicine, St. Louis, MO 63110, USA.

Abstract

Life expectancy in the world has increased dramatically during the last century; the number of older adults is expected to rise while the number of youths will decline in the near future. This demographic shift has considerable public health and economic implications since aging is associated with the development of serious chronic diseases. Calorie restriction (CR) is the most effective nutritional intervention for slowing aging and preventing chronic disease in rodents. In non-human and human primates, CR with adequate nutrition protects against abdominal obesity, diabetes, hypertension and cardiovascular diseases. Cancer morbidity and mortality are also diminished in CR monkeys, and data obtained from individuals practicing long-term CR show a reduction of metabolic and hormonal factors associated with increased cancer risk.

PMID:
21402069
PMCID:
PMC3439843
DOI:
10.1016/j.febslet.2011.03.015
[Indexed for MEDLINE]
Free PMC Article

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