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Bioinformatics. 2011 May 1;27(9):1332-4. doi: 10.1093/bioinformatics/btr124. Epub 2011 Mar 12.

fastsimcoal: a continuous-time coalescent simulator of genomic diversity under arbitrarily complex evolutionary scenarios.

Author information

1
Institute of Ecology and Evolution, University of Berne, Berne, Switzerland. laurent.excoffier@iee.unibe.ch

Abstract

MOTIVATION:

Genetic studies focus on increasingly larger genomic regions of both extant and ancient DNA, and there is a need for simulation software to match these technological advances. We present here a new coalescent-based simulation program fastsimcoal, which is able to quickly simulate a variety of genetic markers scattered over very long genomic regions with arbitrary recombination patterns under complex evolutionary scenarios.

AVAILABILITY AND IMPLEMENTATION:

fastsimcoal is a C++ program compiled for Windows, MacOsX and Linux platforms. It is freely available at cmpg.unibe.ch/software/fastsimcoal/, together with its detailed user manual and example input files.

PMID:
21398675
DOI:
10.1093/bioinformatics/btr124
[Indexed for MEDLINE]

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