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Bioinformatics. 2011 May 1;27(9):1343-4. doi: 10.1093/bioinformatics/btr137. Epub 2011 Mar 12.

UniCarb-DB: a database resource for glycomic discovery.

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  • 1Department of Medical Biochemistry and Cell Biology, University of Gothenburg, Sweden.

Abstract

Glycosylation is one of the most important post-translational modifications of proteins, known to be involved in pathogen recognition, innate immune response and protection of epithelial membranes. However, when compared to the tools and databases available for the processing of high-throughput proteomic data, the glycomic domain is severely lacking. While tools to assist the analysis of mass spectrometry (MS) and HPLC are continuously improving, there are few resources available to support liquid chromatography (LC)-MS/MS techniques for glycan structure profiling. Here, we present a platform for presenting oligosaccharide structures and fragment data characterized by LC-MS/MS strategies. The database is annotated with high-quality datasets and is designed to extend and reinforce those standards and ontologies developed by existing glycomics databases.

AVAILABILITY:

http://www.unicarb-db.org

PMID:
21398669
DOI:
10.1093/bioinformatics/btr137
[PubMed - indexed for MEDLINE]
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