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Cell. 1990 May 4;61(3):535-47.

The roles of Drosophila cyclins A and B in mitotic control.

Author information

1
Department of Biochemistry and Biophysics, University of California, San Francisco 94143.

Abstract

We have cloned, sequenced, and characterized the expression of a Drosophila cyclin B gene. The independent evolutionary conservation of A- and B-type cyclins implies that they have distinct roles. Indeed, in mutant embryos deficient in cyclin A, cells that accumulate only cyclin B do not enter mitosis. Thus, in vivo, cyclin B is not sufficient for mitosis. Furthermore, we find that the two cyclins are coexpressed in all proliferating cells throughout development. Though lacking a formal demonstration that cyclin B is essential as it is in other organisms, we propose that each of these proteins fulfills a distinct and essential role in the cell cycle.

PMID:
2139805
PMCID:
PMC2753431
DOI:
10.1016/0092-8674(90)90535-m
[Indexed for MEDLINE]
Free PMC Article

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