Format

Send to

Choose Destination
Cancer Cell. 2011 Mar 8;19(3):297-9. doi: 10.1016/j.ccr.2011.02.019.

Escaping Anoikis through ROS: ANGPTL4 controls integrin signaling through Nox1.

Author information

1
Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX, USA.

Abstract

Reactive oxygen species (ROS) mediate various cell fate decisions in normal and transformed cells. In this issue of Cancer Cell, Zhu et al. demonstrate the ability of ANGPTL4 to engage integrin-dependent survival signals by activation of the NADPH oxidase Nox1, thus mimicking anchorage conditions and bypassing anoikis by controlling ROS.

PMID:
21397852
DOI:
10.1016/j.ccr.2011.02.019
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center