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Dev Cell. 2011 Mar 15;20(3):289-90. doi: 10.1016/j.devcel.2011.02.012.

Stopped in translation: EMT control meets eukaryotic elongation.

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1
Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA. zhangyin@mail.nih.gov

Abstract

Recently reporting in Molecular Cell, Hussey et al. (2011) find that hnRNP E1 inhibits the translation of several genes essential for the epithelial-to-mesenchymal transition (EMT) by blocking eEF1A1 release during translation elongation. Phosphorylation of hnRNP E1 in response to TGF-β signaling disrupts the hnRNP E1-eEF1A1 interaction, triggering EMT.

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