Format

Send to

Choose Destination
See comment in PubMed Commons below
Neurosci Lett. 2011 May 2;494(3):202-6. doi: 10.1016/j.neulet.2011.03.013. Epub 2011 Mar 21.

Involvement of the AATn polymorphism of the CNR1 gene in the efficiency of procedural learning in humans.

Author information

1
Lab. Neurogenómica Cognitiva, Depto. Psicofisiología, Fac. Psicología, Universidad Nacional Autónoma de México (UNAM), Mexico City, Mexico. aleruiz@servidor.unam.mx

Abstract

Procedural learning refers to the acquisition of motor skills and the practice that refines their performance. The striatum participates in this learning through a function regulated by endocannabinoid signaling and other systems. This study relates the efficiency in learning a procedural task with the AATn polymorphism of the CNR1 gene, which encodes for the CB1 receptor. The mirror-drawing star task was solved by 99 healthy young subjects in three trials. The sample was divided into high- and low-performance groups based on performance efficiency. AAT12/14 carriers were more frequent in the former group, while there were more AAT12/13 carriers in the latter, which also made more errors/min. Therefore, we characterized two efficiency phenotypes: high- vs. low-performers associated with the two AATn genotypes, AAT12/14 vs. AAT12/13. The findings suggest that AATn polymorphism modifies CNR1 translation, indicating a different modulation of CB1.

PMID:
21396980
DOI:
10.1016/j.neulet.2011.03.013
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center