Send to

Choose Destination
See comment in PubMed Commons below
Magn Reson Med. 2011 Jul;66(1):187-91. doi: 10.1002/mrm.22794. Epub 2011 Mar 9.

On the mechanisms enabling myocardial edema contrast in bSSFP-based imaging approaches.

Author information

Department of Radiology, Northwestern University, Chicago, Illinois, USA.


The biophysical mechanisms influencing balanced steady-state free precession (bSSFP) based edema imaging in the setting of acute myocardial infarction are not well understood. To assess the various mechanisms that enable the detection of myocardial edema on bSSFP-based imaging approaches (cine bSSFP and T(2)-prepared bSSFP), experiments were conducted in canine models subjected to ischemia-reperfusion injury. Results showed that in addition to relaxation effects, the alteration in thermal equilibrium (M(0)) (including magnetization transfer) has a significant contribution to the image contrast between edematous and healthy myocardium. The relative signal-intensity ratios between edematous and healthy myocardium were: 1.51 ± 0.18 (cine bSSFP) and 1.58 ± 0.20 (T(2)-prepared bSSFP); the theoretically estimated relative relaxation and M(0) effects were: 1.17 ± 0.09 and 1.30 ± 0.19, respectively (cine bSSFP), and 1.49 ± 0.23 and 1.06 ± 0.07, respectively (T(2)-prepared bSSFP). There were no significant difference between cine bSSFP and T(2)-prep bSSFP relative signal-intensity ratios. However, the relative relaxation effect in cine bSSFP was significantly lower than in T(2)-prep bSSFP (P < 0.05), and the M(0) effect in cine bSSFP was significantly higher than in T(2)-prep bSSFP (P < 0.05). Hence the acquisition strategies that wish to maximize myocardial edema contrast in cine bSSFP imaging should take both relaxation and M(0) effects into account.

[Indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons


    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Support Center