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Cell Tissue Bank. 2012 Jun;13(2):203-15. doi: 10.1007/s10561-011-9248-2. Epub 2011 Mar 11.

Historical perspectives and the future of adverse reactions associated with haemopoietic stem cells cryopreserved with dimethyl sulfoxide.

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Danish Medicines Agency, Axel Heides Gade 1, 2300, Copenhagen S, Denmark.


A retrospective review of the published literature identified several hundred adverse reactions (e.g. nausea, chills, cardiac arrhythmias, neurological symptoms and respiratory arrest) associated with the transplantation of stem cells cryopreserved with dimethyl sulfoxide. The occurrences of these are generally accepted as commonplace, as the majority of reactions are transient, whilst a few patients may require clinical treatment. This exploratory study is a collation of the historical data and the expectations for the notification of serious adverse reactions. Outline information is presented on the development of related European Directives, some technical aspects of dimethyl sulfoxide and the sequential stages of preservation and administration.

[Indexed for MEDLINE]

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