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Nat Rev Immunol. 2011 Apr;11(4):275-88. doi: 10.1038/nri2939. Epub 2011 Mar 11.

Immunity to fungal infections.

Author information

1
Department of Experimental Medicine and Biochemical Sciences, Microbiology Section, University of Perugia, Via del Giochetto, 06122 Perugia, Italy. lromani@unipg.it

Abstract

Fungal diseases represent an important paradigm in immunology, as they can result from either a lack of recognition by the immune system or overactivation of the inflammatory response. Research in this field is entering an exciting period of transition from studying the molecular and cellular bases of fungal virulence to determining the cellular and molecular mechanisms that maintain immune homeostasis with fungi. The fine line between these two research areas is central to our understanding of tissue homeostasis and its possible breakdown in fungal infections and diseases. Recent insights into immune responses to fungi suggest that functionally distinct mechanisms have evolved to achieve optimal host-fungus interactions in mammals.

PMID:
21394104
DOI:
10.1038/nri2939
[Indexed for MEDLINE]

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