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Indian J Pathol Microbiol. 2011 Jan-Mar;54(1):170-2. doi: 10.4103/0377-4929.77394.

Naturally occurring anti M complicating ABO grouping.

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Royal Darwin Hospital, NT, Australia.


Anti M is considered a naturally occurring antibody that is usually active at temperatures below 37°C and is thus of no clinical significance. This antibody, if present in an individual, can lead to a discrepancy between forward and reverse ABO grouping and thus creates diagnostic difficulties for blood bank staff. We report a case of a 58-year-old lady who had an unexpected reaction in reverse grouping due to anti M that posed a problem for us in the interpretation of results of her blood group. We also reviewed the literature to find out the significance of such discrepancy in blood grouping.

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