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Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Mar 1;67(Pt 3):386-9. doi: 10.1107/S1744309111000571. Epub 2011 Feb 25.

Crystallization of the Staphylococcus aureus MazF mRNA interferase.

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1
Structural Biology Brussels, Department of Molecular and Cellular Interactions, Vrije Universiteit Brussel, Pleinlaan 2, B-1050 Brussel, Belgium.

Abstract

mazEF modules encode toxin-antitoxin pairs that are involved in the bacterial stress response through controlled and specific degradation of mRNA. Staphylococcus aureus MazF and MazE constitute a unique toxin-antitoxin module under regulation of the sigB operon. A MazF-type mRNA interferase is combined with an antitoxin of unknown fold. Crystals of S. aureus MazF (SaMazF) were grown in space group P2(1)2(1)2(1). The crystals diffracted to 2.1 Å resolution and are likely to contain two SaMazF dimers in the asymmetric unit.

PMID:
21393849
PMCID:
PMC3053169
DOI:
10.1107/S1744309111000571
[Indexed for MEDLINE]
Free PMC Article
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